The Bene Gesserit's complex relationship with forbidden Thinking Machines in the Dune universe revealed, as the series and films offer conflicting portrayals.
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In the Dune: Prophecy series, the Bene Gesserit use Thinking Machines, which is banned by the Imperium, to further their secret plans of genetic engineering for ideal rulers - a plot point adapted from the Sisterhood of Dune books.
The Dune films, however, depict the Bene Gesserit as strictly adhering to the 'Great Commandment' of not creating machines in the likeness of a human mind, contradicting the Prophecy series and the original novels.
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Valya Harkonnen, Tula Harkonnen, Raquella, Dorotea, Bene Gesserit, Imperium, Emperor Corrino, Dune: Prophecy, Dune films, Sisterhood of Dune